Role of cGMP/PKG in fat tissue
نویسنده
چکیده
Background With more than half a billion adults world-wide being obese, obesity has reached pandemic dimensions. Thus, regulation of fat cell differentiation and function is of great interest for pharmacological research. The cyclic GMP (cGMP) signaling cascade plays an outstanding role in the cardiovascular system. Several studies demonstrate that cGMP signaling plays also an important role in fat tissue. Interestingly, essential components of the cGMP pathway have been found in both white (WAT) and brown (BAT) adipose tissue. White adipocytes mainly store energy in form of lipids, whereas brown fat cells dissipate energy in form of heat.
منابع مشابه
Cardiac natriuretic peptides promote adipose ‘browning’ through mTOR complex-1
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